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Although trace metals such as iron and copper are essential for numerous physiological processes, their accumulation or dysregulation can lead to the generation of ROS, contributing to oxidative damage, lipid peroxidation, and impairment of both enzymatic and non-enzymatic antioxidant defenses [69]

This elicits a response in the output (or effector) domain, which is usually involved in transcription, but can also have enzymatic function

Superresolution imaging of ribosomes and RNA polymerase in live Escherichia coli cells

doi: 10.1016/j.nicl.2016.10.007, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Hersman S., Hoffman A

Nanoemulsion containing kojic dipalmitate and Rosehip oil: a promising formulation to treat melasma

Compounds designed to stabilize Golgi integrity, such as brefeldin A analogs, have been shown to restore normal lipid metabolism and trafficking in experimental models (89)