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126 Recognizing the role of manganese in activating the cGAS-STING pathway, Huang et al developed a novel nanotheranostic system known as MCCS

Mechanistically, CAT promotes ubiquitination and proteasomal degradation of HIF-1, thereby attenuating osteoclast differentiation and bone resorption (Figure 4)

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Indeed, we demonstrated that GSH finely compensates the decline of SOD1 activity in: (i) cells expressing less active SOD1 mutant found in familial amyotrophic lateral sclerosis (Vigilanza et al., 2008)

[DOI] [PubMed] [Google Scholar] 219.Sargeant L., Jaeckel A., Wareham N