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Variations in mtDNA have been demonstrated to impair mitochondrial respiratory chain function, resulting in diminished ATP availability, augmented generation of ROS, and, in turn, oxidative damage to both nuclear and mitochondrial genomes

This points to a possible role in healthy aging

The mtDNA mutation load was then determined, and cells with the desired mutation loads were selected, expanded in culture, and used for subsequent experiments

Anti-epileptic activity of daidzin in PTZ-induced mice model by targeting oxidative stress and BDNF/VEGF signaling

Mitophagy is a mechanism that selectively removes damaged mitochondria through autophagy during cell evolution, and timely removal of damaged mitochondria plays a significant role in maintaining the normal physiologic functions of cells
