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Selenium had, for most of its early scientific life, a difficult reputation
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In one investigation, GHK-Cu was speculated to upregulate tight junction proteins ZO-1 and occludin in a co-culture model of epithelial-macrophage interaction (via the SIRT1/STAT3 pathway), thereby supporting tissue-barrier integrity in inflamed mucosa
10.1016/j.phymed.2022.154090 14
