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The deficiency worsens with age and is accelerated by chronic illness, medications, and environmental toxins

Chicago: The Open Court

DOI: 10.1001/jamanetworkopen.2024.18383 UK NICE

Mutant huntingtin directly disrupts cholesterol biosynthesis by suppressing sterol regulatory element-binding proteins, leading to significantly reduced total cholesterol levels in neurons and brain tissues of patients with HD and transgenic animal models (168-172)

doi: 10.1212/WNL.0000000000010725

If the TSH is elevated, the person probably has an underactive thyroid gland, and its enlargement may be a sign of autoimmune thyroiditis
