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Furthermore, because some NAPQI is created regardless of the function of the other 2 pathways, failure in the glutathione-dependent pathway is expected to result in the accumulation of NAPQI and subsequent toxicity, even if the other 2 pathways are functional

Kanwal, R., & Gupta, S

Manufacturers need to implement rigorous testing protocols to ensure the purity of their glutathione and to verify that it remains in the reduced form throughout the production process and product shelf-life

Biomed Pharmacother 107:262269 Messina A, Monda V, Sessa F, Valenzano A, Salerno M, Bitetti I, Precenzano F, Marotta R et al (2018) Sympathetic, metabolic adaptations, and oxidative stress in autism spectrum disorders: how far from physiology

This can mean a reduced ability to do everything from working around the house, performing at your job, exercising, and enjoying recreational activities