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In AD affected brain regions, neprilysin is oxidatively modified by HNE and has decreased levels and activity [62

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Similarly, the results from a population-based cohort study demonstrated the linkage between low-selenium levels in toenails with OA-associated pain and disease severity 26,27

EAAC1 gene expression is promoted by nuclear factor erythroid 2-related factor 2 (Nrf2) [64], regulatory factor X1 (RFX1) [65], and all-trans-retinoic acid (ATRA) [66], while miR-96-5p, which is one of the microRNAs (miRNAs), has a target sequence in the 3-UTR of EAAC1 and suppresses the protein expression of EAAC1 posttranslationally, leading to decreased GSH levels in the brain [67,68] (Figure 3)