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Phase II enzymes such as GSTP1 and GSTA1, found in several mammalian species and non-tumorous liver tissues [14] are the first step in the mercapturic acid pathway, which leads to the excretion of the xenobiotics

These morphologic findings correlate with an early selective depolarization of the resting membrane potentiation, attributed to a decrease in the activity of the electrogenic Na + /K + -ATPase, that results in an enhancement of the efficacy of excitatory inputs to these interneurons (Ross and Soltesz, 2000)

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