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During this bottleneck period, homocysteine levels rise temporarily, producing nausea and gastrointestinal irritation through direct mucosal interaction and altered gut motility signaling

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If cancer isnt a major concern, are there other concerns about these drugs

What's actually serving a purpose

There is no established safety data for the combination in any population, so the honest position is that contraindication data does not exist at the combination level

Ipilimumab was added after disease recurrence