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doi: 10.3389/fbioe.2021.671321 Received 23 February 2021 Accepted 26 March 2021 Published 16 April 2021 Volume 9 - 2021 Edited by Yi-Rui Wu, Shantou University, China Reviewed by Xiaoyuan Wang, Jiangnan University, China

Approximately 50% of ingested TMAO is absorbed unchanged and then excreted in urine

doi: 10.20463/jenb.2018.0026

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Despite some positive findings for acute and chronic studies, only three research groups performed muscle biopsies, and all three found no change in skeletal muscle content of L-carnitine, indicating no practical reason to supplement with L-carnitine alone (3, 4, 30)

Khedr NF, El-Feky OA, Werida RH (2022) L-Carnitine mitigates Trazadone induced rat cardiotoxicity mediated via modulation of autophagy and oxidative stress