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Levels of PPAT, the key enzyme of de novo purine nucleotide synthesis, are increased in TC tissues, enhancing PKM2 expression and activating extracellular signal-regulated kinase (ERK) and signal transducer of activation 3 (STAT3) signaling pathways [73]

Elsherbiny NM, Sharma I, Kira D, Alhusban S, Samra YA, Jadeja R, et al

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During the early stages of cancer progression, new blood vessels were restructured from the pre-existing blood vessels through a process called angiogenesis which helps tumor cell proliferation and survival by supplying the nutrients and oxygen [50, 51]

119 [online] Available at: Department of health and social care (2021) Folic acid added to flour to prevent spinal conditions in babies [online] GOV.UK, Available at: (accessed 5th April 2022) Derbyshire, E