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10.1038/nm.2279 27 Bor LuenT

Incretin receptor agonists, including tirzepatide, may potentially increase the risk of thyroid C-cell tumors based on findings in animal studies

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Intestinal epithelial architecture and metabolism The intestinal epithelium is a multicellular interface located in close proximity to a complex and dense microbial milieu

Next to the initial model substrate D1 bearing a 5-aminohexyl moiety, three phosphorothioate oligonucleotides (including multiple LNA modifications) bearing different 5-modifications were investigated

This disruption allows neurotoxic plasma components, blood cells, and pathogens to enter the brain, leading to increased ROS production, mitochondrial dysfunction, and inflammation