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Dysregulated Eicosanoid Signaling in Disease The tight regulation of eicosanoid biosynthesis means that dysregulation whether through increased production, decreased metabolism, or altered receptor expression contributes to the pathogenesis of diverse diseases
Methods Enzymol 252:3853
In addition, once MODS develops, the gut is continuously injured by a combination of factors intrinsic to critical illness (dysbiosis, ischemia, etc.) and unintended consequences of interventions not aimed at the gut but that injure components of the gut (proton pump inhibitors, antibiotics, opioids, etc.)
To enhance therapy for deep-seated melanoma, Wang et al
A.VanniP.MaggiS.PerissinottoE.et al
That framing matters because bioavailability is often used imprecisely
