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Another open-label, randomized, controlled trial evaluated the effect of citicoline (1,000 mg/day for 12 months) in 347 subjects (mean age, 67.2 years) who suffered an acute stroke

Note that this is a two-electron (2e + 2H + ) oxidation an alcohol to a ketone
[DOI] [PubMed] [Google Scholar] 63.Fiorenza M., Hostrup M., Gunnarsson T.P., Shirai Y., Schena F., Iaia F.M., Bangsbo J

Week 3-4 (1 Month): With consistent weekly injections, improved diet, and regular exercise, some patients begin noticing changes in how their body processes fat
McConnell HW, Mitchell SC, Smith RL, Brewster M (1997)
For example, OPRM1 rs1799971 is present in 3% of African Americans (AA), 14% of Europeans (NFE), 17% of Latinos, and 38% of East Asians