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As mentioned above, GSH is synthesized only in the cytoplasmic matrix, but it is also found in intracellular organelles, including the mitochondria, nucleus, and endoplasmic reticulum

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In vivo biodistribution indicated enhanced delivery of pioglitazone-loaded NLC into the brain after nasal administration, demonstrating the potential of NLC as a carrier for pioglitazone in AD treatment

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Whether oral use is appropriate depends on the patients symptoms, product quality, treatment goal, and provider recommendation

In a similar way to that reported for sodium selenite, Kim and collaborators [71] demonstrated that superoxide anion generated by selenite triggered mitochondrial damage, subsequent mitophagy and cell death in glioma cells