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Description
Therefore, to provide a more applicable mechanistic insight, we aimed to identify the key bacteria responsible for TMAO formation from carnitine by establishing a series of TMAO-productivity-directed humanized gnotobiotic mice (hGM) models (Fig

Humanized gnotobiotic mouse experiments C57BL/6JNarl male germ-free mice (812 weeks of age) were used to establish four study groups of hGM model through fecal microbiota transplantation (FMT) from donors of two OCCT-defined high-TMAO producers (O15 and O32) and two OCCT-defined low-TMAO producers (V12 and V25)

Scaricamazza S, et al

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This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors