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They may include increased GSH utilization upon exposure to oxygen, insufficient GSH synthesis due to immature synthesis enzymes or to reduced availability of cysteine, the rate-limiting precursor amino acid for GSH synthesis, or impaired regeneration of oxidized glutathione (GSSG) to GSH

doi: 10.1016/j.jep.2014.07.031 285 SartaSDumanHKaravS

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In MASLD, elevated CCL2 levels exacerbate liver inflammation by enhancing monocyte and macrophage infiltration [196]

Wang Y, Zhang C, Xiao M, Ganesan K, Gao F, Liu Q et al (2023) A tumor-targeted delivery of oral isoliquiritigenin through encapsulated zein phosphatidylcholine hybrid nanoparticles prevents triple-negative breast cancer