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[DOI] [PMC free article] [PubMed] [Google Scholar] 87.Dhanya R., Arya A.D., Nisha P., Jayamurthy P

Matt Kaeberlein (UW Medicine, Optispan) observed: Expecting a single drug to meaningfully alter the course of Alzheimers once cognitive decline is underway is an extraordinarily high bar. The EVOKE population already had MCI or mild dementiameaning pathological cascades were well-established

However, a post hoc analysis evaluating the efficacy in patients without extremely high serum levels of LPS did demonstrate benefit in survival and mean arterial blood pressure in treated patients compared to sham controls [332]

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PLOS One 10, e0142225