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Funding This work was supported by the National Natural Science Foundation of China (82130109, 81773924), Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (2021-I2M-1-020), Natural Science Foundation of Hunan (2021JJ30512), Natural Science Foundation of Changsha (kq2014091), and General Projects of Education Department of Hunan Province (No 19C1406), The Hunan University of Chinese Medicine First-class Disciple Construction Project of Chinese Material Medica (No 201803)

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Phase II clinical trials (RGN-259) have evaluated the efficacy of topical ophthalmic thymosin beta-4 in the treatment of dry eye disease and neurotrophic corneal lesions, with encouraging results