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This oligomerization leads to protein toxic stress, ultimately inducing cell death

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doi: 10.1016/j.tcm.2012.08.005 91 PiomboniPFocarelliRStendardiAFerramoscaAZaraV

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Br J Clin Pharmacol 59:491494 Bailey WJ, Holder D, Patel H, Devlin P, Gonzalez RJ, Hamilton V, Muniappa N, Hamlin DM, Thomas CE, Sistare FD, Glaab WE (2012) A performance evaluation of three drug-induced liver injury biomarkers in the rat: alpha-glutathione S-Transferase, Arginase 1, and 4-Hydroxyphenyl-Pyruvate dioxygenase