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In vitro metabolism of helenalin acetate and 11,13-dihydrohelenalin acetate: Natural sesquiterpene lactones from Arnica

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One possible explanation for the association between the use of calcium channel blockers and elevated concentrations of serum urate and a reduced risk of Parkinson's disease is their ability to reduce oxidative stress in neurons that are vulnerable to degeneration in Parkinson's disease

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Core molecular mechanisms include the specific oxidative modification of host proteins by HOCl generated via myeloperoxidase catalysis [398], the oxidative activation of NLRP3 inflammasome [399], and HIF-1-mediated gut microbiota dysbiosis [400]