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doi: 10.1046/j.1440-1746.2001.02376.x

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In previous studies, p53 TAD was shown to significantly influence the DNA selectivity of p53 DBD, with the acidic residues of TAD believed to contribute to this selectivity through interactions with the basic residues of DBD 54

Despite a relatively short half-life of approximately 30 minutes, the peptide triggers gene expression changes that persist and cascade independently of its continued presence

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