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An initial study suggested that neuron-specific Gpx4 depletion caused neurodegeneration, suggesting the possible involvement of ferroptosis in various neurodegenerative diseases, such as Alzheimers disease (AD) and Parkinsons disease (PD) 19
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Under these conditions FAT/CD36 is depalmitoylated, a reaction catalyzed by the LYPLA1 (lysophospholipase 1) gene
