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Accordingly, missense DNA mutations that impair G6PD activity or stability result in increased oxidative stress and a spectrum of disease phenotypes featuring, most commonly, hemolytic anemia, and collectively called G6PD deficiency 1

Oncotarget 8(17):2806328073 Hayano M, Yang WS, Corn CK et al (2016) Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

However, additional randomized clinical studies are needed to define its effectiveness in this setting

Conversion of BaP (1) to quinone species occurs via cytochrome CYP450 peroxidase activity (Figure 1)