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The -subunit starts with the remaining part of the spliced ID/FnIII-2 domain, followed by the FnIII-3 domain, the transmembrane helix (TM), juxtamembrane (JM) and TK modules 7

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Given the described D1R-GHSR1a dimer, one could propose that GHSR antagonism reduces the reinforcing effects of drugs of abuse like alcohol, nicotine, and cocaine by reducing D1 receptor signaling produced by the D1R-GHSR1a dimer

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10.1039/c4fo00088a 61 MirzaeeF.HosseiniA.JouybariH