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Conversion is fine for most healthy younger adults, but can be less efficient in people with MTHFR genetic variants (an estimated 25 to 40% of the population carries at least one variant), people with liver function decline (more common with age), and smokers and former smokers

Thus, its effects on choline and acetylcholine levels in the brain are similar to those of deanol but appear to be about twice as effective [54]

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Many users combine both approaches, injecting for overall support while applying topical formulations to particularly problematic loose skin areas

Symptoms can include persistent fatigue, brain fog, weakness, low mood or irritability, numbness or tingling in the hands or feet, dizziness, and difficulty concentrating