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10.1074/jbc.M116.734533 21 DeNicolaG

Protein not absorbed in the small intestine undergoes microbial fermentation in the colon, producing branched-chain fatty acids (BCFAs), ammonia, hydrogen sulfide, and phenolic compounds

doi: 10.1016/0022-2828(91)90084-Y
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A.GazzinelliR

However, during APAP overdose, the excessive production of NAPQI overwhelms the cellular antioxidant capacity, leading to the accumulation of NAPQI-protein adducts
