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The antibodies prevent the B12 from binding to the intrinsic factor resulting in a deficiency

Chronic exposure to the anesthetic gas, nitrous oxide, can cause an acquired, functional B12 deficiency (174176)
[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Granneman JG, Moore H-PH, Granneman RL, Greenberg AS, Obin MS, Zhu Z
