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The reversible nature of Grx2 is associated with its sensitivity to changes in GSH/GSSG

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[Crossref] [PubMed] Hanzelmann S, Castelo R, Guinney J

Histones that are retained are visible in gene clusters of imprinted sort and therefore protamination as well as changes within residual histones may be the common cause of paternal infertility

Its long-term effectiveness and safety remain inconclusive
