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The reversible nature of Grx2 is associated with its sensitivity to changes in GSH/GSSG

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[Crossref] [PubMed] Hanzelmann S, Castelo R, Guinney J

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Histones that are retained are visible in gene clusters of imprinted sort and therefore protamination as well as changes within residual histones may be the common cause of paternal infertility

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Its long-term effectiveness and safety remain inconclusive

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