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Critical appraisal The most detailed mechanistic information is provided by cell culture studies that show dose-dependent inhibition of uPA and uPAR expression, plasmin activity, and reduced cell migration and invasion in cancerous cell lines of breast, colon, hepatocellular carcinoma, and osteosarcoma ([336]

Increasing the synthesis of acetyl-CoA through glucose metabolism drives the production of cellular energy and promotes cell proliferation 34

NMDA receptors, when overactive, contribute to excitotoxicity and excessive neural firing

Among these, monocyte chemoattractant protein 1 (MCP-1) (29), also known as CC chemokine ligand 2, is classified within the CC subfamily of chemokines

Combined use of diane-35 and metformin improves the ovulation in the pcos rat model possibly via regulating glycolysis pathway