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[DOI] [PubMed] [Google Scholar] Waxman A., Restrepo-Jaramillo R., Thenappan T., Ravichandran A., Engel P., Bajwa A., Allen R., Feldman J., Argula R., Smith P., Rollins K., Deng C., Peterson L., Bell H., Tapson V., Nathan S

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Its currently classified as an elective treatment or alternative medicine rather than a medically necessary procedure for FDA-approved conditions

GR has also two Cys residues that form a redox-active disulfide bridge at the active site

Based on these reports, the anti-cancer properties of berberine can be regarded by stimulating both endogenous and exogenous apoptosis via increasing the protein expression of pro-apoptotic molecules Bax, Bad, Bak, and activating Caspase-3, Caspase-8 and Caspase-9

Wang et al., 1997