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Subjects with pre-existing hypertension (defined as baseline systolic BP 130 mmHg) showed significantly higher adverse event rates: 32% experienced blood pressure increases exceeding 20 mmHg, compared to 6% in normotensive controls

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Although polyclonal immunoglobulins are more likely to cause interferences in immunoassays due to the so-called paraproteins, which are usually monoclonal but can also be polyclonal intact immunoglobulins or immunoglobulinic fragments (frequently light chains but also heavy chains) frequently produced by a malignant cone of B cells

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doi:10.1016/0141-0229(89)90133-6

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