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[DOI] [PubMed] [Google Scholar] 419.Kim M.E., Kim D.H., Lee J.S

Antioxid Redox Signal 10, 445473, doi: 10.1089/ars.2007.1716 (2008)

Most people experience noticeable changes within 3 to 6 treatment sessions that are done at a few weeks interval

These metabolic disturbances lead to hepatic lipid accumulation, Kupffer cell activation, and NLRP3 inflammasome signaling

When intra-portal insulin levels are increased (e.g., obesity, Cushings syndrome, or due to treatment with glucocorticoids and glucagon-like peptide 1 receptor agonists) or decreased (e.g., malnutrition, anorexia nervosa and type 1 diabetes mellitus), these changes secondarily alter hepatic GH sensitivity resulting in a secondary association with discordant GH and IGF-I levels (e.g., high GH/low IGF-I levels or low GH/high IGF-I levels, respectively)