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Importantly, protein adducts on mitochondria are most critical for toxicity because they trigger initial oxidative stress, which is amplified through a mitogen-activated protein (MAP) kinase cascade with the ultimate activation of c-jun N-terminal kinase (JNK)

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[DOI] [PubMed] [Google Scholar] 256.Elia D, Stadler K, Horvth V, Jakus J

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Copper redox silencing: The copper tripeptides copper is tightly coordinated (log K = 16.44) with documented silencing of redox activity
