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4,5 Dietary insufficiency, pernicious anemia (i.e., an autoimmune process that reduces available intrinsic factor and subsequent absorption of vitamin B 12 1,2,6,7 ), and long-term use of metformin or acid-suppressing medications have been implicated in B 12 deficiency

Boosting NAD + levels through the PreissHandler pathway is achievable through NA supplementation 28,29

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Initial titration over 714 days allows researchers to identify dose-limiting side effects before committing to higher therapeutic doses

Generally, a healthy diet rich in meat, fish and dairy products provide a natural source of vitamin B12 required for the body, but it may be deficient in vegetarians and vegans