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Stimulating effects of H 2 S on glycolytic metabolism in cancer cells have been demonstrated to result from per-sulphidation of lactate dehydrogenase (LDH, particularly the LDH-A isoform) 149,150 and glyceraldehyde-3-phosphate dehydrogenase, although the functional consequences of per-sulphidation of the latter appear to be controversial

Pham, M

From these investigations, it becomes obvious that in situations of sulfur starvation the rate of glutathione and cysteine degradation must exceed glutathione and cysteine synthesis due to the reduced ability of the cell to perform sulfur assimilation into cysteine

Rashmi Sarkar, Pooja Arora, 1 and K Vijay Garg

doi: 10.1371/journal.pone.0227377