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This phenotypic plasticity underscores macrophages as the central orchestrators of immune-mediated renal injury in DKD ( Figure 2 )

Failure to do so may lead to a variety of health issues, including anemia, fatigue, muscle weakness, intestinal problems, nerve damage, and mood disturbances

[20] Aphthous stomatitis occurs worldwide, but is more common in developed countries

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The goal is to identify which of the four biological systems is the most relevant entry point for that specific patient

Murine daily dose: 1,2502,500 mcg/day (murine-equivalent for a ~25 g mouse), given as two divided doses