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Wilson, A., Platt, R., Wu, Q., Leclerc, D., Christensen, B., Yang, H., Rozen, R

A method for preventing radiation-induced ototoxicity in an individual in need thereof comprising intratympanic administration of a pharmaceutical composition comprising a therapeutic agent selected from a JNK inhibitor, TRPV modulator, an MET channel inhibitor, and an otoprotectant to the individual in need thereof, wherein the pharmaceutical composition is administered prior to onset of radiation therapy, and wherein the composition provides sustained release of the therapeutic agent into the ear for a period of at least 5 days after a single administration

By targeting tumor-associated antigens and delivering highly potent cytotoxic payloads, ADCs can achieve selective killing of tumor cells while minimizing toxic damage to normal tissues [22,32,33,50]

Kraus, D

19 About 1030% of DVT and pulmonary embolism episodes cause death within 30 days (with the risk of death being higher in pulmonary embolism), and the 10-year mortality rate among those with venous thromboembolism is reported to be as high as 40%

Therefore, compared to other forms like Setria L-glutathione, its efficacy remains a matter of ongoing research and debate