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Treatment with TF drastically maintained the intracellular iron level close to the control level (Fig

Therefore, validation of results in primary cells is a fundamental step

a dermatologic condition that leads to skin atrophy)

Notably, the combination of pembrolizumab with platinum-based regimens has been evaluated in many cancers including NSCLC, SCLC, gastric, gastro-oesophageal junction, ovarian, urinary tract, endometrial, and BTC (NCT02549209, NCT02578680, NCT02580994, NCT02608684, NCT02853305, NCT02954536, NCT03029598, NCT03066778, NCT03664024, NCT03675737, NCT03582475, and NCT04003636) [100,101,102,103,104,105,106,107,108,109,110,111]
It is generated in cells during various metabolic processes, primarily as a byproduct of the electron transport chain in mitochondria

Curr Anal Chem 14(5):512518 Wang R, Yang Z, Zhang J, Mu J, Zhou X, Zhao X (2019) Liver injury induced by carbon tetrachloride in mice is prevented by the antioxidant capacity of Anji white tea polyphenols
