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In addition to S586A, S586G and S586T retained more than 10% activity toward tyrosine, whereas the other mutants showed less than 5% or undetectable activity toward tyrosine or DOPA (Fig
Considering the complex pathophysiological mechanisms of diseases such as bronchiectasis, combination application strategies of DPP1 inhibitors with other therapeutic drugs merit in-depth study ( Establishment of long-term safety assessment systems proves essential
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Knauthe R
[DOI] [PubMed] [Google Scholar] 131.Fisher CM
