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Alcohol and smoking deplete glutathione levels and reduce supplement effectiveness
It is extremely easily oxidized to disulfide bonds, forming inactive oxidized glutathione (GSSG)

CrossRef The relationship of the clinicopathological characteristics and treatment results of post-Chornobyl papillary thyroid microcarcinomas with the latency period and radiation exposure Tetiana Bogdanova, Serhii Chernyshov, Liudmyla Zurnadzhy, Tatiana I

[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Berndt C, Poschmann G, Stuhler K, Holmgren A, Brautigam L

Accordingly, dysregulation of the FeS clusters biogenesis, including decreased expression of NFS1, has also been described as being relevant in mechanisms of resistance to cancer therapy
