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As time passes, natural levels of NAD diminish, leading to fatigue, mental decline, and rapid aging

However, if extremely high doses are given for a long time, pyridoxine can cause nerve damage leading to numbness or tingling in the hands and feet (peripheral neuropathy)

[DOI] [PMC free article] [PubMed] [Google Scholar] 139.Peclat, T

However, there is no a unique pattern of expression of these molecules for each subtype suggesting that each patient should be considered as a specific case
