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Additional studies focus on heterocyclic carboxamides such as TXA00182, an effective efflux pump inhibitor when used with monobactam, fluoroquinolones, sulfonamides, and tetracycline 81

Hyaluronidase is an enzyme that breaks down hyaluronic acid and can aid in the correction

doi: 10.1038/s41420-019-0166-6 283 SahaSButtariBProfumoETucciPSasoL

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Sabuncu T, Harma M, Harma M, Nazligul Y, Kilic F

These antibodies are produced by plasma cells in the synovium, where, in addition to these cells, innate immune cells (monocytes, dendritic cells, mast cells) and adaptive immune cells (T helper 1 and T helper 17 lymphocytes [Th1 and Th17, respectively]) are also present, along with B lymphocytes and fibroblast-like synoviocytes (FSL) [17]