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3.2 Nanoparticles enhance NK cells function Nanoparticles can also exert anti-tumor immunity by enhancing NK cells function in addition to promoting the homing of NK cells to the tumor site, such as SeNPs designed with neutral (polyvinylpyrrolidone-PVP), anionic (citric acid-LET) and cationic (chitosan-CS) surfactants, which can not only trigger more NK cells in mouse but also effectively activate NK cells (78)