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For instance, Ahmadi et al

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Oxidative stress injury can derive from impaired mitochondria with excessive levels of reactive oxygen species (ROS), because ROS are a byproduct of adenosine triphosphate (ATP) generation

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The effects of a B12 injection vary for each individual and are influenced by diet and underlying medical conditions

Many practitioners suggest using both since NAD+ increases mitochondrial activity and produces more reactive oxygen species, while glutathione neutralizes these byproducts