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In such severe cases, cerebral oedema becomes clinically apparent 12 hours to 4 days after the overdose [18, 20, 50, 87], although CNS depression may be delayed if a slow-release preparation has been ingested [12, 50]

However, single and incomplete mixtures resulted in abnormal lamellar bodies and a structurally imbalanced lipid matrix, whereas the complete lipid mixtures produced normal lamellar bodies and lipid bilayers

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