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[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Raimundo N

2.1 Study design In this prospective, double-blind, cross-over interventional study, patients were randomized in balanced blocks (1:1) into two groups: Sequence 1, HA-first, received the control product (containing only hyaluronic acid 0.2%) for 4 weeks, followed by a 1-week washout, and then the experimental product (hyaluronic acid 0.2% + butyroyl glutathione 0.4%) for 4 weeks

Occasionally, patients may experience mild gastrointestinal upset or headache related to the niacinamide component

Over time, an unaddressed deficiency can cause irreversible nerve damage, highlighting the urgency of early detection

SCFAs also activate G-protein-coupled receptors (GPCRs) and modulate histone acetylation, thereby influencing immune tolerance [96]

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