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As NAD+ decreases, mitochondrial oxidative phosphorylation suffers, which produces less ATP and more reactive oxygen species (ROS)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Grimm D., Streetz K

[DOI] [PubMed] [Google Scholar] MacFarlane 2011 MacFarlane AJ, GreeneFinestone LS, Shi Y