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Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, Mu N, Gu J, Zhang W, Wang Y, Zhang Y, Zhang W

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But, the growing number of patients with no or low response to PDE5I, and the potential of adverse reactions have prompted the development of safer and more effective treatments ( Figure 1 Drug therapy: Phosphodiesterase 5 inhibitors Phosphodiesterase 5 (PDE5) is highly expressed in vascular smooth muscle and it is the most common PDE subtype in penile smooth muscle

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Most patients with mildly elevated B12 and no identified pathology require only periodic monitoring with reassurance once serious causes have been excluded

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