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In a study of patients with chronic low back pain, Vitamin B12 given for 2 weeks reduced pain by 32% compared to placebo [Chiu, 2011] In a 2020 systematic review looking at the use of B12 for nerve-related pain it was found that there is moderate evidence for the therapeutic effect of B12 in the treatment painful peripheral neuropathy [Julian, 2020]

doi: 10.1080/09638288.2017.1383518 [DOI] [PMC free article] [PubMed] [Google Scholar] 583

whereas the plasma GPx activity is mostly due to GPx3, based on the relative expression levels of these GPx enzymes intracellularly and extracellularly and their relative sensitivity to selenium-mediated changes in expression compared with GPx4